A Bill is the draft of a legislative proposal. It has to pass through various stages before it becomes an Act of Parliament.First Reading
The legislative process starts with the introduction of a Bill in either House of Parliament-Lok Sabha or Rajya Sabha. A Bill can be introduced either by a Minister or by a private member. In the former case it is known as a Government Bill and in the latter case it is known as a Private Member's Bill.It is necessary for a member-in-charge of the Bill to ask for leave to introduce the Bill. If leave is granted by the House, the Bill is introduced. This stage is known as the First Reading of the Bill. If the motion for leave to introduce a Bill is opposed, the Speaker may, in his discretion, allow brief explanatory statement to be made by the member who opposes the motion and the member-in-charge who moved the motion. Where a motion for leave to introduce a Bill is opposed on the ground that the Bill initiates legislation outside the legislative competence of the House, the Speaker may permit a full discussion thereon. Thereafter, the question is put to the vote of the House. However, the motion for leave to introduce a Finance Bill or an Appropriation Bill is forthwith put to the vote of the House.
Publication in GazetteAfter a Bill has been introduced, it is published in the Official Gazette. Even before introduction, a Bill might, with the permission of the Speaker, be published in the Gazette.In such cases, leave to introduce the Bill in the House is not asked for and the Bill is straightaway introduced.Reference of Bill to Standing Committee
After a Bill has been introduced, Presiding Officer of the concerned House can refer the Bill to the concerned Standing Committee for examination and make report thereon.If a Bill is referred to Standing Committee, the Committee shall consider the general principles and clauses of the Bill referred to them and make report thereon. The Committee can also take expert opinion or the public opinion who are interested in the measure. After the Bill has thus been considered, the Committee submits its report to the House. The report of the Committee, being of persuasive value shall be treated as considered advice given by the Committees.
Second ReadingThe Second Reading consists of consideration of the Bill which is in two stages.First Stage: The first stage consists of general discussion on the Bill as a whole when the principle underlying the Bill is discussed. At this stage it is open to the House to refer the Bill to a Select Committee of the House or a Joint Committee of the two Houses or to circulate it for the purpose of eliciting opinion thereon or to straightaway take it into consideration.If a Bill is referred to a Select/Joint Committee, the Committee considers the Bill clause-by-clause just as the House does. Amendments can be moved to the various clauses by members of the Committee. The Committee can also take evidence of associations, public bodies or experts who are interested in the measure. After the Bill has thus been considered, the Committee submits its report to the House which considers the Bill again as reported by the Committee. If a Bill is circulated for the purpose of eliciting public opinion thereon, such opinions are obtained through the Governments of the States and Union Territories. Opinions so received are laid on the Table of the House and the next motion in regard to the Bill must be for its reference to a Select/Joint Committee. It is not ordinarily permissible at this stage to move the motion for consideration of the Bill.Second Stage: The second stage of the Second Reading consists of clause-by-clause consideration of the Bill as introduced or as reported by Select/Joint Committee.Discussion takes place on each clause of the Bill and amendments to clauses can be moved at this stage. Amendments to a clause have been moved but not withdrawn are put to the vote of the House before the relevant clause is disposed of by the House. The amendments become part of the Bill if they are accepted by a majority of members present and voting. After the clauses, the Schedules if any, clause 1, the Enacting Formula and the Long Title of the Bill have been adopted by the House, the Second Reading is deemed to be over.Third Reading
Thereafter, the member-in-charge can move that the Bill be passed. This stage is known as the Third Reading of the Bill. At this stage the debate is confined to arguments either in support or rejection of the Bill without referring to the details thereof further than that are absolutely necessary. Only formal, verbal or consequential amendments are allowed to be moved at this stage. In passing an ordinary Bill, a simple majority of members present and voting is necessary. But in the case of a Bill to amend the Constitution, a majority of the total membership of the House and a majority of not less than two-thirds of the members present and voting is required in each House of Parliament.Bill in the other House
After the Bill is passed by one House, it is sent to the other House for concurrence with a message to that effect, and there also it goes through the stages described above except the introduction stage.Money Bills
Bills which exclusively contain provisions for imposition and abolition of taxes, for appropriation of moneys out of the Consolidated Fund, etc., are certified as Money Bills. Money Bills can be introduced only in Lok Sabha. Rajya Sabha cannot make amendments in a Money Bill passed by Lok Sabha and transmitted to it. It can, however, recommend amendments in a Money Bill, but must return all Money Bills to Lok Sabha within fourteen days from the date of their receipt. It is open to Lok Sabha to accept or reject any or all of the recommendations of Rajya Sabha with regard to a Money Bill. If Lok Sabha accepts any of the recommendations of Rajya Sabha, the Money Bill is deemed to have been passed by both Houses with amendments recommended by Rajya Sabha and accepted by Lok Sabha and if Lok Sabha does not accept any of the recommendations of Rajya Sabha, Money Bill is deemed to have been passed by both Houses in the form in which it was passed by Lok Sabha without any of the amendments recommended by Rajya Sabha. If a Money Bill passed by Lok Sabha and transmitted to Rajya Sabha for its recommendations is not returned to Lok Sabha within the said period of fourteen days, it is deemed to have been passed by both Houses at the expiration of the said period in the form in which it was passed by Lok Sabha.
Sunday, June 12, 2011
HOW A BILL BECOMES AN ACT
Labels:
POLITY
Saturday, June 11, 2011
Madhya Pradesh P.S.C. (Pre.) Exam. 2010 Solved Paper
Indian History
(Exam Held on 20-2-2011)
(Exam Held on 20-2-2011)
1. Where is the Indus Civilization city Lothal ?
(A) Gujarat
(B) Rajasthan
(C) Punjab
(D) Haryana
Ans : (A)
2. Mohenjo Daro is situated in—
(A) Sindh Province of Pakistan
(B) Gujarat
(C) Punjab
(D) Afghanistan
Ans : (A)
3. Which deity was not worshipped by the Vedic Aryans ?
(A) Indra
(B) Marut
(C) Varun
(D) Pashupati
Ans : (D)
4. The Vedanga consists of the—
(A) Kalp, Shiksha, Nirukta, Vyakaran, Chhanda, Jyotish
(B) Kalp, Shiksha, Brahman, Vyakaran, Chhanda, Jyotish
(C) Kalp, Shiksha, Nirukta, Aranyak, Chhanda, Jyotish
(D) Kalp, Upanishad, Nirukta, Vyakaran, Chhanda
Ans : (A)
5. The earliest available work of the Sangam Tamils is—
(A) Pattinappalai
(B) Tirumurugarruppadai
(C) Maduraikanchi
(D) Tolkappiyam
Ans : (D)
6. The Mahavir belonged to the clan—
(A) Kalams
(B) Bhaggas
(C) Lichhivis
(D) Bulis
Ans : (C)
7. The Jain text which contains the biographies of the Tirthankaras is known as—
(A) Bhagwatisutra
(B) Uvasagadasao
(C) Adi Purana
(D) Kalpasutra
Ans : (D)
8. The first Buddhist Sangeeti (conference) was held at—
(A) Vaishali
(B) Pataliputra
(C) Rajgriha
(D) Ujjain
Ans : (C)
9. The propounder of the Madhyamika Philosophy was—
(A) Bhadrabahu
(B) Parshwanath
(C) Sheelbhadra
(D) Nagarjuna
Ans : (D)
10. The rules of Buddhist monistic life are laid down, primarily, in—
(A) Tripitaka
(B) Vinayapitaka
(C) Abhidhammapitaka
(D) Suttapitaka
Ans : (B)
11. The battle between Alexander and Porus took place on the bank of river—
(A) Sutlej
(B) Ravi
(C) Jhelum
(D) Ganga
Ans : (C)
12. The first Persian ruler who occupied part of Indian Territory was—
(A) Cyrus
(B) Darius I
(C) Cambyses
(D) Xerxes
Ans : (B)
13. Alexander remained in India for—
(A) 29 months
(B) 39 months
(C) 19 months
(D) 10 months
Ans : (C)
14. Gedrosia corresponds to modern—
(A) Baluchistan
(B) Lahore
(C) Multan
(D) Peshawar
Ans : (A)
15. Which of the following statements is not true ?
(A) Formal accession of Asoka was very probably delayed
(B) The fifth rock edict proves the existence of Harems of Asoka’s brothers
(C) Asoka held the viceroyalty of Taxila and Ujjain in the reign of Bindusara
(D) Asoka was the younger brother of Bindusara
Ans : (D)
16. The nirvasita (excluded) and anirvasita (not excluded) Shudras have been referred to—
(A) in the Nirukta of Yaska
(B) in the Ashtadhyayi of Panini
(C) in the Arthashastra of Kautilya
(D) None of the above
Ans : (D)
17. The first translator of Mahabharata into Tamil was—
(A) Perundevanar
(B) Kamban
(C) Sundaramurthi
(D) Bharavi
Ans : (A)
18 Which one of the following inscriptions of Asoka refers to the grant of concession in land revenue to a village ?
(A) Lumbini Pillar edict
(B) Sarnath Pillar edict
(C) Girnar Rock edict
(D) Sanchi Pillar edict
Ans : (A)
19. Who of the following was not a patron of Jainism ?
(A) Bimbisara
(B) Kharvela
(C) Kanishka
(D) Chandragupta Maurya
Ans : (A)
20. Who was the ambassador in the Court of Bindusara ?
(A) Machiavelli
(B) Megasthenes
(C) Deimachus
(D) Antiochus I
Ans : (C)
21. To propagate his Dhamma, Asoka used the services of—
(A) Rajukas
(B) Pradeshikas
(C) Yuktas
(D) All of these
Ans : (D)
22. The last king of Mauryan empire was—
(A) Devavarman
(B) Brihadrath
(C) Kunala
(D) Shalishuk
Ans : (B)
23. The historian Kalhan was—
(A) Buddhist
(B) Brahmin
(C) Jain
(D) None of these
Ans : (B)
24 Founder of the Satvahana dynasty was—
(A) Shatkarni I
(B) Simuka
(C) Shatkarni II
(D) Rudradaman I
Ans : (B)
25. Yen-Kao-Chen is generally known as—
(A) Kadphises I
(B) Kadphises II
(C) Kanishka
(D) Vasishka
Ans : (B)
26. The writer of the ‘Kalpasutra’ was—
(A) Simuka
(B) Panini
(C) Bhadrabahu
(D) Patanjali
Ans : (C)
27. The writer of the ‘Brihatkatha’ was—
(A) Dattamitra
(B) Gudadhya
(C) Bhadrabahu
(D) Sarvavarman
Ans : (B)
28. According to tradition Kashyapa Matanga introduced Buddhism to—
(A) China
(B) Kashmir
(C) Ceylon
(D) Gandhar
Ans : (A)
29. Which one of the following indicates the correct chronological order of era in India ?
(A) Gupta—Harsha—Vikram—Shaka
(B) Vikram—Harsha—Gupta—Shaka
(C) Gupta—Shaka—Vikram—Harsha
(D) Vikram—Shaka—Gupta—Harsha
Ans : (D)
30. During Pre-Gupta period what was Kahapan ?
(A) An office
(B) A luxury item
(C) A coin
(D) A port
Ans : (C)
31. Which port was known to the author of “Periplus of the Erithrian Sea” as Padouke ?
(A) Tamralipti
(B) Arikmedu
(C) Broach
(D) Cochin
Ans : (B)
32 Chandragupta-II married his daughter Prabhavati to—
(A) Rudrasena-I
(B) Rudrasena-II
(C) Agnimitra
(D) Nagsena
Ans : (B)
33. Which of the following law givers of the post-Gupta period declared that Sudras were not slaves by nature ?
(A) Medhatithi
(B) Vigynaeshwar
(C) Narad
(D) Jimutwahan
Ans : (A)
34. Who was the founder of Gahadwala dynasty who made Kannauj the main centre of his power ?
(A) Jaichandra
(B) Vijaychandra
(C) Chandradev
(D) Govind
Ans : (C)
35. Which of the following Rashtrakut kings defeated the Pratihar ruler Nagabhatta I ?
(A) Indra II
(B) Krishna III
(C) Amoghvarsha I
(D) Govind III
Ans : (D)
36. Who among the following rulers patronized Jayadev, the composer of ‘Geetgovinda’ ?
(A) Laxman Sen
(B) Kharvel
(C) Kumarpala
(D) Shashank
Ans : (A)
37. Who out of the following ousted Jainism from Mysore ?
(A) Naynars
(B) Lingayats
(C) Alwars
(D) Shankaracharya
Ans : (D)
38. Which was the word used for the royal military troops of the Cholas ?
(A) Kattupaddi
(B) Kaikkolar
(C) Bhrtaka
(D) Kadgham
Ans : (B)
39. The Chola rulers undertook extensive land survey to ascertain—
(A) Right of ownership
(B) Government’s share of revenue
(C) Production of grains
(D) Limit of the sources of irrigation
Ans : (B)
40. Which of the following taxes of Chola period was for educational purpose ?
(A) Devadana
(B) Salabhoga
(C) Brahmadeva
(D) Sarvamanya
Ans : (A)
41. The writer of Tabqat-i-Nasiri was—
(A) Barani
(B) Nizamuddin
(C) Minhaj-us-Siraj
(D) Isami
Ans : (C)
42. The following works were written by Ziauddin Barani—
(A) Tarikh-i-Firozshahi and Qiranussadain
(B) Fatwa-i-Jahandari and Ashiqa
(C) Tarikh-i-Firozshahi and Fatwa-i-Jahandari
(D) Futuhus-salatin and Tarikhi-Firozshahi
Ans : (C)
43. Which of the following books were written by Amir Khusro ?
(A) Ashiqa, Qiranussadain, Khazain-ul-Futuh
(B) Qiranussadain, Ashiqa, Tarikh-i-Mubarakshahi
(C) Khazainul Futuh, Tarikh-i-Mubarakshahi, Ashiqa
(D) Tarikh-i-Mubarakshahi, Nuh-i-Siphr, Ashiqa
Ans : (A)
44. Who wrote ‘Qanun-i-Humayuni’ ?
(A) Gulbadan Begum
(B) Yahya
(C) Khwandmir
(D) Nizamuddin
Ans : (C)
45. Which of the following books was written by Ishwardas Nagar ?
(A) Futuhat-i-Alamgiri
(B) Bir Binod
(C) Chhatra Prakash
(D) Ahkam-i-Alamgiri
Ans : (A)
46. With whom of the following Muhammad Ghori aligned against Khusrau Shah ?
(A) King of Gujarat
(B) King of Multan
(C) King of Peshawar
(D) King of Jammu
Ans : (D)
47. At the time of Muhammad Ghori’s invasion against Prithviraj Chauhan who of the following ruled Kannauj ?
(A) The Chandellas
(B) The Pratihars
(C) The Palas
(D) The Gahadwalas
Ans : (D)
48. Who of the following contested with Qutubuddin Aibak for Punjab ?
(A) Ikhtiyaruddin
(B) Tajuddin Yaldauz
(C) Nasiruddin Qubacha
(D) None of these
Ans : (B)
49. Who were the Nav Musalmans of the following ?
(A) Descendants of Mongols who settled near Delhi and embraced Islam
(B) Hindu converts to Islam
(C) Khalji Sultans
(D) Ilbari Sultans
Ans : (A)
50. Who was appointed as ambassador to China during the time of Mohammad bin Tughlaq ?
(A) Barbosa
(B) Barani
(C) Ibn Batutah
(D) Abdur Razzak
Ans : (C)
51. Bahlul Lodi’s significant achievement was the successful war against the underwritten kingdom of—
(A) Mewat
(B) Jaunpur
(C) Chandwar
(D) Sambhal
Ans : (B)
52. Rulers of which kingdom built Atala Masjid and Lal Darwaza Masjid ?
(A) Bengal
(B) Khandesh
(C) Malwa
(D) Jaunpur
Ans : (D)
53. Rai Bharmal wrote on Muslim Literary traditions in the following language—
(A) Persian
(B) Sanskrit
(C) Arabic
(D) Turkish
Ans : (A)
54. ‘Chaitanya Charitamrita’ was authored by—
(A) Wasweshwara
(B) Madhav
(C) Ramanand
(D) Krishnadas Kaviraj
Ans : (D)
55. Who succeeded Nizamuddin Aulia ?
(A) Sheikh Farid
(B) Sheikh Nasiruddin Chiraghi-Delhi
(C) Sheikh Salim Chishti
(D) None of the above
Ans : (B)
56. Raidas, Sena and Kabir were the followers of—
(A) Namdeo
(B) Ramanuj
(C) Vallabhacharya
(D) Ramanand
Ans : (D)
57. When was Vijayanagar visited by Abdurrajjak ?
(A) 1443
(B) 1433
(C) 1423
(D) 1427
Ans : (A)
58. Tuluva dynasty was founded by—
(A) Narasa Nasyaka
(B) Immadi Narsimha
(C) Vir Narsimha
(D) None of these
Ans : (C)
59. Who founded the independent Bahamani kingdom in South India ?
(A) Abu Muzaffar Alauddin Bahmanshah
(B) Mujahid Shah
(C) Muhammad Shah I
(D) Adil Shah
Ans : (A)
60. Who founded the independent Muslim kingdom of Malwa ?
(A) Hoshangshah
(B) Mahmudshah
(C) Nasiruddin
(D) Dilawarkhan
Ans : (D)
61. Babur had three wives. Which one of the following was not his wife ?
(A) Maham
(B) Gulrus
(C) Gulbadan
(D) Dilbar
Ans : (C)
62. Who was Mehdi Khwaza ?
(A) Ruler of Bihar
(B) Prime Minister of Ibrahim Lodi
(C) Brother-in-law of Humayun
(D) Brother of Babur
Ans : (C)
63. Humayun ascended the throne at Agra on—
(A) 7th January 1530
(B) 29th December 1530
(C) 23rd September 1530
(D) 16th February 1530
Ans : (B)
64. Which of the following statements is true of the Sher Shah Suri ?
(A) He was a fanatic Muslim
(B) He was a staunch Muslim but not a fanatic
(C) He was a staunch Muslim and ill-treated Hindus
(D) He was intolerant towards other religions
Ans : (B)
65. Which out of the following was not one of the purposes of ‘Sarais’ built during Sher Shah ?
(A) Post-house
(B) For travellers
(C) For officers
(D) Warehouse for arms and ammunition
Ans : (D)
66. Who was not appointed as Vazir during Akbar’s reign ?
(A) Bahadurkhan Uzbeg
(B) Shamsuddin Atkakhan
(C) Todarmal
(D) Nizamuddin Khalifa
Ans : (A)
67. Which of the following pairs is incorrect ?
(A) Akbar—Ralph Fich
(B) Darashikoh—Manucci
(C) Jahangir—Sir Thomas Roe
(D) Shah Jahan—Jourdon
Ans : (D)
68. Which of the following statements is true of Akbar’s policy towards the Hindus ?
(A) He abolished the pilgrim tax but not the Jaziya
(B) He abolished the Jaziya, but not the pilgrim tax
(C) He abolished both the Jaziya and the pilgrim tax
(D) He neither abolished the pilgrim tax nor the Jaziya
Ans : (C)
69 Who was the author of ‘Nuskhai-Dilkusha’ ?
(A) Khafi Khan
(B) Murshidkuli Khan
(C) Abul Fazl
(D) Bhimsen Burhanpuri
Ans : (D)
70. Guru Govind Singh was killed in 1708 at—
(A) Amritsar
(B) Keeratpur
(C) Nanded
(D) Anandpur
Ans : (C)
71. Mir Sayyed Ali and Abdusamad were the court painter during the time of—
(A) Humayun, Akbar
(B) Akbar, Jahangir
(C) Jahangir, Shah Jahan
(D) Shah Jahan, Aurangzeb
Ans : (A)
72. Which of the following elements was not found in Akbar’s architecture ?
(A) Use of red sandstone
(B) Hindu elements
(C) Foliated arches
(D) Charbagh surrounding the tombs
Ans : (C)
73. Who composed ‘Ganga Lahri’ ?
(A) Tulsidas
(B) Surdas
(C) Panditraj Jagannath
(D) Haridasa
Ans : (C)
74. Which of the following was not a silver coin during Akbar ?
(A) Jalal
(B) Dam
(C) Darab
(D) Pandau
Ans : (B)
75. Which of the following revolts had agrarian causes at its root ?
(A) Rajput revolt
(B) Satnami and Jat revolt
(C) Sikh revolt
(D) Maratha revolt
Ans : (B)
76. From whom Shahji received the jagir of Poona ?
(A) Mughals
(B) Adilshah
(C) Nizamshahi
(D) Portuguese
Ans : (B)
77. What is ‘Mokasa’ ?
(A) Jagir
(B) Religious practice
(C) Cavalry
(D) Religious endowment
Ans : (A)
78. Who was not alive at the time of Shivaji’s Coronation ?
(A) Ganga Bhatt
(B) Tukaram
(C) Ramdas
(D) Dadaji Konddeva
Ans : (D)
79. Which of the following Peshwas is connected with the treaty of Sagola ?
(A) Balaji Bajirao
(B) Balaji Vishwanath
(C) Bajirao I
(D) Bajirao II
Ans : (A)
80. In which year Ahilyabai Holkar breathed her last ?
(A) 1792
(B) 1793
(C) 1794
(D) 1795
Ans : (D)
81. The French East India Company was formed in—
(A) 1664 AD
(B) 1660 AD
(C) 1656 AD
(D) 1680 AD
Ans : (A)
82. La Bourdonnais was the Governor of—
(A) Madras
(B) Pondicherry
(C) Mauritius
(D) None of these
Ans : (B)
83. Mir Kasim removed his court from Calcutta to—
(A) Patna
(B) Dacca
(C) Monghir
(D) Purnea
Ans : (C)
84. The battle of Wandiwash was fought between—
(A) English and the French
(B) English and the Marathas
(C) English and the Nawab of Carnatic
(D) English and Hyderali
Ans : (A)
85. At the battle of Biddera the English crushed the power of—
(A) French
(B) Dutch
(C) Portuguese
(D) Danes
Ans : (B)
86. The Treaty of Surat was concluded by the British with the following Maratha chief—
(A) Narayan Rao
(B) Madhav Rao
(C) Nana Phadnvis
(D) Raghoba
Ans : (D)
87. The triple alliance against Tipu was formed by Cornwallis consisted of the following—
(A) The English, Nizam and the Marathas
(B) The English, Nizam and Awadh
(C) The English, Nizam and Carnatic
(D) The English, Marathas and Carnatic
Ans : (A)
88. In the Second Sikh War the decisive battle was fought at—
(A) Chilianwala
(B) Peshawar
(C) Gujarat
(D) Multan
Ans : (C)
89. In the Third Maratha War, the English defeated Peshwa Bajirao II at—
(A) Mahidpur
(B) Sitabuldi
(C) Kirki
(D) Bassein
Ans : (D)
90. The Treaty of Shrirangpattam took place in—
(A) 1791
(B) 1792
(C) 1793
(D) 1794
Ans : (D)
91. Which of the following states was not annexed to British Empire by Dalhousie under the doctrine of Lapse ?
(A) Baghat
(B) Nagpur
(C) Sambalpur
(D) Benaras
Ans : (D)
92. Which one of the following rebellions is associated with Sidhu and Kanhu ?
(A) Munda Rebellion
(B) Kole Rebellion
(C) Santhal Rebellion
(D) Bhil Rebellion
Ans : (C)
93. The following officer was connected with the suppression of Thugee—
(A) Hastings
(B) Sleeman
(C) Bentinck
(D) Aukland
Ans : (C)
94. Which of the following British Officers was not in favour of annexation of Awadh ?
(A) Outram
(B) Napier
(C) Hugh Rose
(D) Sleeman
Ans : (D)
95. Charles Metcalf was the Governor General of India during—
(A) 1835-36
(B) 1839-40
(C) 1837-38
(D) 1832-33
Ans : (A)
96. Sindh was invaded during the following Governor General’s time—
(A) Lord Aukland
(B) Lord Ellenborough
(C) Lord Hardinge
(D) Lord Dalhousie
Ans : (B)
97. The Second Burmese War was fought in the year—
(A) 1849
(B) 1850
(C) 1851
(D) 1852
Ans : (B)
98. Which one of the following Acts abolished the trading rights of the East India Company ?
(A) Regulating Act of 1773
(B) Charter Act of 1813
(C) Charter Act of 1833
(D) Charter Act of 1853
Ans : (B)
99. Which one of the following pairs is not correctly matched ?
(A) Ryotwari Settlement : Madras
(B) Talukdari Settlement : Bombay
(C) Permanent Settlement : Bengal
(D) Mahalwari Settlement : North-Western Province
Ans : (B)
100. The gradual increase in rural indebtedness in India under the British rule was due to—
1. Fragmentation of Landholdings
2. Decline of cottage industries
3. Lack of development of irrigational facilities
4. Introduction of cash crops Which of these are correct ?
(A) 1, 2 and 3
(B) 2 and 4
(C) 1, 3 and 4
(D) 1, 2, 3 and 4
Ans : (D)
101. At Lucknow the revolt of 1857 broke out on—
(A) May 30, 1857
(B) June 4, 1857
(C) May 15, 1857
(D) June 15, 1857
Ans : (B)
102. The Asiatic Society of Bengal in Calcutta was founded by—
(A) Raja Ram Mohan Roy
(B) Sir Williams Jones
(C) Warren Hastings
(D) Keshabchandra Sen
Ans : (B)
103. The Theosophical Society allied itself to the—
(A) Christian revival movement
(B) Islamic revival movement
(C) Hindu revival movement
(D) All of these
Ans : (C)
104. Which of the following statements about the Ramakrishna Mission is wrong ?
(A) It held the pure Vedantic doctrine as its ideal
(B) It aimed at the development of the highest spirituality in man
(C) It prohibited the worship of images
(D) It recognised modern developments in Science and Technology
Ans : (C)
105. Fifth Session of the Indian National Congress was held in 1889 at—
(A) Calcutta
(B) Madras
(C) Bombay
(D) Dacca
Ans : (C)
106. The moderates and extremists were united in the Congress Session of—
(A) Lahore
(B) Bombay
(C) Allahabad
(D) Lucknow
Ans : (D)
107. Who among the following was not in Khilafat Committee ?
(A) Majhar ul Haq
(B) Hasrat Mohani
(C) Maulana Shauqat Ali
(D) Hakim Azmalkhan
Ans : (A)
108. Who among the following was the president of All India Trade Union Congress in 1929 ?
(A) M. N. Roy
(B) N. M. Joshi
(C) Jawaharlal Nehru
(D) Jayaprakash Narayan
Ans : (B)
109. Swaraj Party was formed by—
(A) C. R. Das
(B) Motilal Nehru
(C) Jawaharlal Nehru
(D) C. R. Das and Motilal Nehru
Ans : (D)
110. ‘Lucknow Pact’ was concluded between—
(A) Congress and the British Government
(B) Muslim League and the British Government
(C) Congress and the Muslim League
(D) Congress, the Muslim League and the British Government
Ans : (C)
111. An All Party Conference appointed a sub-committee with Ali Imam, Tejbahadur Sapru and Subhash Bose. Who was presiding this subcommittee ?
(A) Maulana Azad
(B) Vallabh Bhai Patel
(C) Madan Mohan Malviya
(D) Motilal Nehru
Ans : (D)
112. Who among the following participated in all the three Round Table Conferences ?
(A) Madan Mohan Malviya
(B) B. R. Ambedkar
(C) Sardar Patel
(D) None of these
Ans : (B)
113. Which of the following pairs is correct ?
(A) Ramprasad Bismil : Second Lahore Conspiracy Case
(B) Surya Sen : Chatgaon Case
(C) Bhagat Singh : Kakori Conspiracy Case
(D) Chandrashekhar Azad : Delhi Bomb Case
Ans : (B)
114. When were the Congress Governments formed in seven out of eleven provinces ?
(A) July 1935
(B) July 1936
(C) July 1937
(D) July 1938
Ans : (C)
115. Which of the following pairs is correct ?
(A) Chelmsford : Rowlatt Act
(B) Lord Reading : Delhi Darbar
(C) Lord Willington : Arriving of Prince of Wales in India
(D) Lord Hardinge : II Round Table Conference
Ans : (A)
116. Subhash Chandra Bose inaugurated the government of Free India at—
(A) Burma
(B) Japan
(C) Germany
(D) Singapore
Ans : (D)
117. In December 1931 two school girl students killed the District Judge in Komilla by shooting—
(A) Suniti Choudhary and Bina Das
(B) Shanti Ghosh and Suniti Choudhary
(C) Bina Das and Kalpana Datta
(D) Kalpana Datta and Shanti Ghosh
Ans : (B)
118. Which of the following pairs is correct ?
(A) Chuar Revolt : Orissa
(B) Sanyasi Revolt : Bihar
(C) Parlakhemundi Revolt : Orissa
(D) Rampa Revolt : Karnatak
Ans : (B)
119. The following countries undertook the responsibility of organising the Bandung Conference—
(A) Indonesia, Burma, Cambodia
(B) India, Burma, Indonesia
(C) Sri Lanka, Indonesia, Cambodia
(D) China, Japan, Thailand
Ans : (B)
120. Which of the following Articles of Indian Constitution declares it is a primary duty of the state to raise the level of nutrition and the standard of living of its people and the “Improvement of the Public Health” ?
(A) Article 46
(B) Article 47
(C) Article 48
(D) Article 49
Ans : (B)
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APPSC GROUP-2,
HISTORY
Thursday, June 9, 2011
U.N. Convention against Corruption Ratified by India
India ratified the United Nations Convention against Corruption on May 12, 2011. The convention, which is the first legally binding international instrument used to fight corruption, sets out ways for countries to prevent and criminalize corruption, and it requires countries to return assets obtained through corruption to the state from which they came. According to convention, member-countries are bound to render mutual legal assistance towards prosecution of offenders as well in tracing, freezing, and confiscating the proceeds of corruption.
The ratification by India comes as the country reels from several corruption scandals that have led to everything from sacked ministers to hunger strikes. In its resolution 55/61 of 4 December 2000, the General Assembly recognized that an effective international legal instrument against corruption, independent of the United Nations Convention against Transnational Organized Crime (resolution 55/25) was desirable and decided to establish an ad hoc committee for the negotiation of such an instrument in Vienna at the headquarters of the United Nations Office on Drugs and Crime.
The text of the United Nations Convention against Corruption was negotiated during seventh sessions of the Ad Hoc Committee for the Negotiation of the Convention against Corruption, held between 21 January 2002 and 1 October 2003.
The Convention approved by the Ad Hoc Committee was adopted by the General Assembly by resolution 58/4 of 31 October 2003. The General Assembly, in its resolution 57/169 of 18 December 2002, accepted the offer of the Government of Mexico to host a high-level political signing conference in Merida for the purpose of signing the United Nations Convention against Corruption.
In accordance with article 68 (1) of resolution 58/4, the United Nations Convention against Corruption entered into force on 14 December 2005. A Conference of the States Parties is established to review implementation and facilitate activities required by the Convention.
In accordance with article 68 (1) which reads as follows:
"1.This Convention shall enter into force on the ninetieth day after the date of deposit of the thirtieth instrument of ratification, acceptance, approval or accession. For the purpose of this paragraph, any instrument deposited by a regional economic integration organization shall not be counted as additional to those deposited by member States of such organization.
2. For each State or regional economic integration organization ratifying, accepting, approving or acceding to this Convention after the deposit of the thirtieth instrument of such action, this Convention shall enter into force on the thirtieth day after the date of deposit by such State or organization of the relevant instrument or on the date this Convention enters into force pursuant to paragraph 1 of this article, whichever is later."
"1.This Convention shall enter into force on the ninetieth day after the date of deposit of the thirtieth instrument of ratification, acceptance, approval or accession. For the purpose of this paragraph, any instrument deposited by a regional economic integration organization shall not be counted as additional to those deposited by member States of such organization.
2. For each State or regional economic integration organization ratifying, accepting, approving or acceding to this Convention after the deposit of the thirtieth instrument of such action, this Convention shall enter into force on the thirtieth day after the date of deposit by such State or organization of the relevant instrument or on the date this Convention enters into force pursuant to paragraph 1 of this article, whichever is later."
Highlights of Convention
Prevention
Corruption can be prosecuted after the fact, but first and foremost, it requires prevention. An entire chapter of the Convention is dedicated to prevention, with measures directed at both the public and private sectors. These include model preventive policies, such as the establishment of anticorruption bodies and enhanced transparency in the financing of election campaigns and political parties. States must Endeavour to ensure that their public services are subject to safeguards that promote efficiency, transparency and recruitment based on merit. Once recruited, public servants should be subject to codes of conduct, requirements for financial and other disclosures, and appropriate disciplinary measures. Transparency and accountability in matters of public finance must also be promoted, and specific requirements are established for the prevention of corruption, in the particularly critical areas of the public sector, such as the judiciary and public procurement. Those who use public services must expect a high standard of conduct from their public servants. Preventing public corruption also requires an effort from all members of society at large. For these reasons, the Convention calls on countries to promote actively the involvement of non-governmental and community-based organizations, as well as other elements of civil society, and to raise public awareness of corruption and what can be done about it. Article 5 of the Convention enjoins each State Party to establish and promote effective practices aimed at the prevention of corruption.
Criminalization
The Convention requires countries to establish criminal and other offences to cover a wide range of acts of corruption, if these are not already crimes under domestic law. In some cases, States are legally obliged to establish offences; in other cases, in order to take into account differences in domestic law, they are required to consider doing so. The Convention goes beyond previous instruments of this kind, criminalizing not only basic forms of corruption such as bribery and the embezzlement of public funds, but also trading in influence and the concealment and laundering of the proceeds of corruption. Offences committed in support of corruption, including money-laundering and obstructing justice, are also dealt with. Convention offences also deal with the problematic areas of private-sector corruption.
International Cooperation
Countries agreed to cooperate with one another in every aspect of the fight against corruption, including prevention, investigation, and the prosecution of offenders. Countries are bound by the Convention to render specific forms of mutual legal assistance in gathering and transferring evidence for use in court, to extradite offenders. Countries are also required to undertake measures which will support the tracing, freezing, seizure and confiscation of the proceeds of corruption.
Asset Recovery
In a major breakthrough, countries agreed on asset-recovery, which is stated explicitly as a fundamental principle of the Convention. This is a particularly important issue for many developing countries where high-level corruption has plundered the national wealth, and where resources are badly needed for reconstruction and the rehabilitation of societies under new governments. Reaching agreement on this chapter has involved intensive negotiations, as the needs of countries seeking the illicit assets had to be reconciled with the legal and procedural safeguards of the countries whose assistance is sought.
Several provisions specify how cooperation and assistance will be rendered. In particular, in the case of embezzlement of public funds, the confiscated property would be returned to the state requesting it; in the case of proceeds of any other offence covered by the Convention, the property would be returned providing the proof of ownership or recognition of the damage caused to a requesting state; in all other cases, priority consideration would be given to the return of confiscated property to the requesting state, to the return of such property to the prior legitimate owners or to compensation of the victims.
Effective asset-recovery provisions will support the efforts of countries to redress the worst effects of corruption while sending at the same time, a message to corrupt officials that there will be no place to hide their illicit assets. Accordingly, article 51 provides for the return of assets to countries of origin as a fundamental principle of this Convention. Article 43 obliges state parties to extend the widest possible cooperation to each other in the investigation and prosecution of offences defined in the Convention. With regard to asset recovery in particular, the article provides inter alia that "In matters of international cooperation, whenever dual criminality is considered a requirement, it shall be deemed fulfilled irrespective of whether the laws of the requested State Party place the offence within the same category of offence or denominate the offence by the same terminology as the requesting State Party, if the conduct underlying the offence for which assistance is sought is a criminal offence under the laws of both States Parties".
Some of the Scams in India
1) 2G Spectrum Scam
We have had a number of scams in India; but none bigger than the scam involving the process of allocating unified access service licenses. At the heart of this Rs.1.76-lakh crore worth of scam is the former Telecom minister A Raja – who according to the CAG, has evaded norms at every level as he carried out the dubious 2G license awards in 2008 at a throw-away price which were pegged at 2001 prices.
We have had a number of scams in India; but none bigger than the scam involving the process of allocating unified access service licenses. At the heart of this Rs.1.76-lakh crore worth of scam is the former Telecom minister A Raja – who according to the CAG, has evaded norms at every level as he carried out the dubious 2G license awards in 2008 at a throw-away price which were pegged at 2001 prices.
2) Commonwealth Games Scam
Another feather in the cap of Indian scandal list is Commonwealth Games. Even before the long awaited sporting bonanza could see the day of light, the grand event was soaked in the allegations of corruption. It is estimated that out of Rs. 70000 crore spent on the Games, only half the said amount was spent on Indian sportspersons.
The Central Vigilance Commission, involved in probing the alleged corruption in various Commonwealth Games-related projects, has found discrepancies in tenders – like payment to non-existent parties, will-full delays in execution of contracts, over-inflated price and bungling in purchase of equipment through tendering – and misappropriation of funds.
Another feather in the cap of Indian scandal list is Commonwealth Games. Even before the long awaited sporting bonanza could see the day of light, the grand event was soaked in the allegations of corruption. It is estimated that out of Rs. 70000 crore spent on the Games, only half the said amount was spent on Indian sportspersons.
The Central Vigilance Commission, involved in probing the alleged corruption in various Commonwealth Games-related projects, has found discrepancies in tenders – like payment to non-existent parties, will-full delays in execution of contracts, over-inflated price and bungling in purchase of equipment through tendering – and misappropriation of funds.
3) Housing Scam
Congress party politicians, bureaucrats and military officials have been accused of taking over a plush Mumbai apartment block intended for war widows. After the story broke in local media the government sacked the powerful chief minister of western Maharashtra state, who is a member of the Congress party.
Following a CBI probe, the environment ministry ordered the demolition of the 31-storey building in January, citing the violation of environmental and land-use rules. The Arabian Sea-facing block with 103 apartments is built in an upscale Mumbai district. Apartments were sold for as little as $130,000 each, while local media estimated their value at $1.8 million each.
Congress party politicians, bureaucrats and military officials have been accused of taking over a plush Mumbai apartment block intended for war widows. After the story broke in local media the government sacked the powerful chief minister of western Maharashtra state, who is a member of the Congress party.
Following a CBI probe, the environment ministry ordered the demolition of the 31-storey building in January, citing the violation of environmental and land-use rules. The Arabian Sea-facing block with 103 apartments is built in an upscale Mumbai district. Apartments were sold for as little as $130,000 each, while local media estimated their value at $1.8 million each.
4) IPL Scam
The recent scam in IPL and embezzlement with respect to bidding for various franchisees. The scandal already claimed the portfolios of two big-wigs in the form of Shashi Tharoor and former IPL chief Lalit Modi.
The recent scam in IPL and embezzlement with respect to bidding for various franchisees. The scandal already claimed the portfolios of two big-wigs in the form of Shashi Tharoor and former IPL chief Lalit Modi.
5) ISRO and Devas Deal
The deal which caught Antrix in controversy is the Devas deal. Devas is a Bangalore based Multimedia company. The Devas multimedia was set up by one US based company namely Forge Advisors. Most of the members of this Devas multimedia are ex – ISRO officials. The Devas Multimedia had signed a memorandum of understanding (MoU) with Antrix in 2003 . According to this deal, Devas will get 90 % of the S band transponders of two Indian satellites on lease for its digital audio broadcast services. The two new Indian satellites whose S transponders are getting to Devas on deal were GSAT 6 and GSAT 6A.
The deal which caught Antrix in controversy is the Devas deal. Devas is a Bangalore based Multimedia company. The Devas multimedia was set up by one US based company namely Forge Advisors. Most of the members of this Devas multimedia are ex – ISRO officials. The Devas Multimedia had signed a memorandum of understanding (MoU) with Antrix in 2003 . According to this deal, Devas will get 90 % of the S band transponders of two Indian satellites on lease for its digital audio broadcast services. The two new Indian satellites whose S transponders are getting to Devas on deal were GSAT 6 and GSAT 6A.
Devas Multimedia and Antrix signed the contract in 2005 January. But Antrix didn't informed either space commission or union cabinet that the lion portion of the capacity of these satellites will be leased to Devas Multimedia. Usually the S band transponders are used for strategic purposes and here it was leased to a private firm.
6) Loan Bribery Scam
Top officials of Indian banks, lenders and financial firms have been accused of taking bribes to grant corporate loans. The bribes were allegedly paid by private finance firm Money Matters Financial Services (MONE.BO), which acted as a "mediator and facilitator" for the loan beneficiaries.
Top officials of Indian banks, lenders and financial firms have been accused of taking bribes to grant corporate loans. The bribes were allegedly paid by private finance firm Money Matters Financial Services (MONE.BO), which acted as a "mediator and facilitator" for the loan beneficiaries.
7) Telgi Scam
Abdul Karim Telgi had mastered the art of forgery in printing duplicate stamp papers and sold them to banks and other institutions. The tentacles of the fake stamp and stamp paper case had penetrated 12 states and was estimated at a whooping Rs. 20000 crore plus. The Telgi clearly had a lot of support from government departments that were responsible for the production and sale of high security stamps.
Abdul Karim Telgi had mastered the art of forgery in printing duplicate stamp papers and sold them to banks and other institutions. The tentacles of the fake stamp and stamp paper case had penetrated 12 states and was estimated at a whooping Rs. 20000 crore plus. The Telgi clearly had a lot of support from government departments that were responsible for the production and sale of high security stamps.
8) Satyam Scam
The scam at Satyam Computer Services is something that will shatter the peace and tranquillity of Indian investors and shareholder community beyond repair. Satyam is the biggest fraud in the corporate history to the tune of Rs. 14000 crore. The company’s disgraced former chairman Ramalinga Raju kept everyone in the dark for a decade by fudging the books of accounts for several years and inflating revenues and profit figures of Satyam.
The scam at Satyam Computer Services is something that will shatter the peace and tranquillity of Indian investors and shareholder community beyond repair. Satyam is the biggest fraud in the corporate history to the tune of Rs. 14000 crore. The company’s disgraced former chairman Ramalinga Raju kept everyone in the dark for a decade by fudging the books of accounts for several years and inflating revenues and profit figures of Satyam.
9) Bofors Scam
The Bofors scandal is known as the hallmark of Indian corruption. The Bofors scam was a major corruption scandal in India in the 1980s; when the then PM Rajiv Gandhi and several others including a powerful NRI family named the Hindujas, were accused of receiving kickbacks from Bofors AB for winning a bid to supply India’s 155 mm field howitzer.
The Bofors scandal is known as the hallmark of Indian corruption. The Bofors scam was a major corruption scandal in India in the 1980s; when the then PM Rajiv Gandhi and several others including a powerful NRI family named the Hindujas, were accused of receiving kickbacks from Bofors AB for winning a bid to supply India’s 155 mm field howitzer.
The Swedish State Radio had broadcast a startling report about an undercover operation carried out by Bofors, Sweden’s biggest arms manufacturer, whereby $16 million were allegedly paid to members of PM Rajiv Gandhi’s Congress. Most of all, the Bofors scam had a strong emotional appeal because it was a scam related to the defense services and India’s security interests.
10) The Fodder Scam
If you haven’t heard of Bihar’s fodder scam of 1996, you might still be able to recognize it by the name of “Chara Ghotala ,” as it is popularly known in the vernacular language. In this corruption scandal worth Rs.900 crore, an unholy nexus was traced involved in fabrication of “vast herds of fictitious livestock” for which fodder, medicine and animal husbandry equipment was supposedly procured.
If you haven’t heard of Bihar’s fodder scam of 1996, you might still be able to recognize it by the name of “Chara Ghotala ,” as it is popularly known in the vernacular language. In this corruption scandal worth Rs.900 crore, an unholy nexus was traced involved in fabrication of “vast herds of fictitious livestock” for which fodder, medicine and animal husbandry equipment was supposedly procured.
11) The Hawala Scandal
The Hawala case to the tune of $18 million bribery scandal, which came in the open in 1996, involved payments allegedly received by country’s leading politicians through hawala brokers. Thus, for the first time in Indian politics, it gave a feeling of open loot all around the public, involving all the major political players being accused of having accepted bribes and also alleged connections about payments being channelled to Hizbul Mujahideen militants in Kashmir.
The Hawala case to the tune of $18 million bribery scandal, which came in the open in 1996, involved payments allegedly received by country’s leading politicians through hawala brokers. Thus, for the first time in Indian politics, it gave a feeling of open loot all around the public, involving all the major political players being accused of having accepted bribes and also alleged connections about payments being channelled to Hizbul Mujahideen militants in Kashmir.
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Monday, June 6, 2011
E. coli Outbreak in the Europe
Europe is currently besieged by a serious outbreak of a rare strain of E. coli foodborne bacteria. One of the largest outbreaks of E. coli ever recorded strikes Germany and several other European countries. An ongoing Escherichia coli O104:H4 bacterial outbreak began in Germany in May 2011. Certain strains of E. coli are a major cause of foodborne illness. The outbreak started after several people were infected with bacteria leading to hemolytic-uremic syndrome in Germany. Hemolytic-uremic syndrome (HUS) is a medical emergency and requires urgent treatment. 19 people have died by 3 June and around 500 had been hospitalised with HUS due to the intensifying outbreak.
Scientists probing the deadly E. coli strain in Europe are finding the bacteria combines a highly poisonous, but common, toxin with a rarely seen "glue" that binds it to a patient's intestines.
It may take months for the global team of researchers to fully understand the characteristics of the bacteria that has killed at least 17 people in Europe and sickened 1,500. But they fear this E. coli strain is the most toxic yet to hit a human population.
Most Escherichia coli or E. coli bacteria are harmless. The strain that is sickening people in Germany and other parts of Europe, known as 0104:H4, is part of a class of bacteria known as Shiga toxin-producing Escherichia coli, or STEC.
This class has the ability to stick to intestinal walls where it pumps out toxins, causing diarrhea and vomiting. In severe cases, it causes hemolytic uremic syndrome or HUS, attacking the kidneys and causing coma, seizure and stroke.
Germany is now reporting 470 cases of HUS. That is absolutely extraordinary, Dr. Robert Tauxe, a foodborne diseases expert at the U.S. Centers for Disease Control and Prevention, told Reuters. The CDC has been working with German health authorities on the case since late last week.
The main source of E. coli is animal, especially cattle, manure. Ground beef is the main culprit. But because we use manure to fertilize crops, E. coli can also make an appearance in leafy greens, watery vegetables like tomatoes or cucumbers, and sprouts. Finally, E. coli can show up in unpasteurized milk, apple juice, orange juice, or even water. Essentially, everything. The best course of action is to buy quality products from quality vendors who know the source of their meat and produce. Avoid bargain meats, especially those that come from multiple unknown sources. As for vegetables, it's also a good idea to try and buy single source varieties, such as buying heads of lettuce as opposed to the pre-packaged stuff.
Affected countries
- Germany
- Spain
- Sweden
- Czech Republic
- Denmark
- The Netherlands
- United Kingdom
- Switzerland
- Poland
- United States
- Austria
- France
E. coli is Gram-negative, facultative anaerobic and non-sporulating. Cells are typically rod-shaped, and are about 2.0 micrometres (μm) long and 0.5 μm in diameter, with a cell volume of 0.6 – 0.7 (μm)3. It can live on a wide variety of substrates. E. coli uses mixed-acid fermentation in anaerobic conditions, producing lactate, succinate, ethanol, acetate and carbon dioxide. Since many pathways in mixed-acid fermentation produce hydrogen gas, these pathways require the levels of hydrogen to be low, as is the case when E. coli lives together with hydrogen-consuming organisms, such as methanogens or sulphate-reducing bacteria.
Escherichia coli is a Gram-negative, rod-shaped bacterium that is commonly found in the lower intestine of warm-blooded organisms (endotherms). Most E. coli strains are harmless, but some, such as serotype O157:H7, can cause serious food poisoning in humans, and are occasionally responsible for product recalls. The harmless strains are part of the normal flora of the gut, and can benefit their hosts by producing vitamin K2, and by preventing the establishment of pathogenic bacteria within the intestine.
E. coli bacteria are not always confined to the intestine, and their ability to survive for brief periods outside the body makes them ideal indicator organisms to test environmental samples for fecal contamination. The bacterium can also be grown easily, and its genetics are comparatively simple and easily manipulated or duplicated through a process of metagenics, making it one of the best-studied prokaryotic model organisms, and an important species in biotechnology and microbiology.
E. coli was discovered by German pediatrician and bacteriologist Theodor Escherich in 1885, and is now classified as part of the Enterobacteriaceae family of gamma-proteobacteria.
E. coli was discovered by German pediatrician and bacteriologist Theodor Escherich in 1885, and is now classified as part of the Enterobacteriaceae family of gamma-proteobacteria.
E. coli normally colonizes an infant's gastrointestinal tract within 40 hours of birth, arriving with food or water or with the individuals handling the child. In the bowel, it adheres to the mucus of the large intestine. It is the primary facultative anaerobe of the human gastrointestinal tract. (Facultative anaerobes are organisms that can grow in either the presence or absence of oxygen.) As long as these bacteria do not acquire genetic elements encoding for virulence factors, they remain benign commensals.
Virulent strains of E. coli can cause gastroenteritis, urinary tract infections, and neonatal meningitis. In rarer cases, virulent strains are also responsible for haemolytic-uremic syndrome, peritonitis, mastitis, septicaemia and Gram-negative pneumonia.
The antibiotic sensitivities of different strains of E. coli vary widely. As Gram-negative organisms, E. coli are resistant to many antibiotics that are effective against Gram-positive organisms. Antibiotics which may be used to treat E. coli infection include amoxicillin, as well as other semisynthetic penicillins, many cephalosporins, carbapenems, aztreonam, trimethoprim-sulfamethoxazole, ciprofloxacin, nitrofurantoin and the aminoglycosides.
Antibiotic resistance is a growing problem. Some of this is due to overuse of antibiotics in humans, but some of it is probably due to the use of antibiotics as growth promoters in animal feeds. A study published in the journal Science in August 2007 found the rate of adaptative mutations in E. coli is "on the order of 10−5 per genome per generation, which is 1,000 times as high as previous estimates," a finding which may have significance for the study and management of bacterial antibiotic resistance. Antibiotic-resistant E. coli may also pass on the genes responsible for antibiotic resistance to other species of bacteria, such as Staphylococcus aureus, through a process called horizontal gene transfer. E. coli bacteria often carry multiple drug-resistance plasmids, and under stress, readily transfer those plasmids to other species. Indeed, E. coli is a frequent member of biofilms, where many species of bacteria exist in close proximity to each other. This mixing of species allows E. coli strains that are piliated to accept and transfer plasmids from and to other bacteria. Thus, E. coli and the other enterobacteria are important reservoirs of transferable antibiotic resistance.
Resistance to beta-lactam antibiotics has become a particular problem in recent decades, as strains of bacteria that produce extended-spectrum beta-lactamases have become more common.
Phage therapy—viruses that specifically target pathogenic bacteria—has been developed over the last 80 years, primarily in the former Soviet Union, where it was used to prevent diarrhoea caused by E. coli. Presently, phage therapy for humans is available only at the Phage Therapy Center in the Republic of Georgia and in Poland. However, on January 2, 2007, the United States FDA gave Omnilytics approval to apply its E. coli O157:H7 killing phage in a mist, spray or wash on live animals that will be slaughtered for human consumption. The enterobacteria phage T4, a highly studied phage, targets E. coli for infection.
Researchers have actively been working to develop safe, effective vaccines to lower the worldwide incidence of E. coli infection. In March 2006, a vaccine eliciting an immune response against the E. coli O157:H7 O-specific polysaccharide conjugated to recombinant exotoxin A of Pseudomonas aeruginosa (O157-rEPA) was reported to be safe in children two to five years old. Previous work had already indicated it was safe for adults. A phase III clinical trial to verify the large-scale efficacy of the treatment is planned.
In 2006, Fort Dodge Animal Health (Wyeth) introduced an effective, live, attenuated vaccine to control airsacculitis and peritonitis in chickens. The vaccine is a genetically modified avirulent vaccine that has demonstrated protection against O78 and untypeable strains.
In January 2007, the Canadian biopharmaceutical company Bioniche announced it has developed a cattle vaccine which reduces the number of O157:H7 shed in manure by a factor of 1000, to about 1000 pathogenic bacteria per gram of manure.
In April 2009, a Michigan State University researcher announced he had developed a working vaccine for a strain of E. coli. Mahdi Saeed, professor of epidemiology and infectious disease in MSU's colleges of Veterinary Medicine and Human Medicine, has applied for a patent for his discovery and has made contact with pharmaceutical companies for commercial production.
In April 2009, a Michigan State University researcher announced he had developed a working vaccine for a strain of E. coli. Mahdi Saeed, professor of epidemiology and infectious disease in MSU's colleges of Veterinary Medicine and Human Medicine, has applied for a patent for his discovery and has made contact with pharmaceutical companies for commercial production.
E. coli Statistics
General Statistics | ||
1 | Cell length | 2 um or 2x10-6 m |
2 | Cell diameter | 0.8 um or 0.8x10-6 m |
3 | Cell total volume | 1x10-15 L or 1x10-18 m3 (other est. at 0.88x10-15 L) |
4 | Cell aqueous volume | 7 x 10-16 L |
5 | Cell surface area | 6x10-12 m2 |
6 | Cell wet weight | 1x10-15 kg or 1x10-12 g |
7 | Cell dry weight | 3.0x10-16 kg or 3.0x10-13 g |
8 | Periplasm volume | 6.5x10-17 L |
9 | Cytoplasm volume | 6.7x10-16 L |
10 | Envelope volume | 1.6x10-16 L |
11 | Nuclear (DNA+protein) volume | 1.6x10-16 L |
12 | Inner Membrane thickness | 8x10-9 m |
13 | Outer Membrane thickness | 8x10-9 - 15x10-9 m |
14 | Periplasm thickness | 1x10-8 m |
15 | Average size of protein | 360 residues |
16 | Average diameter of ave. protein | 5 nm |
17 | Average MW of protein | 40 kD |
18 | Average prot. oligomerization state | 4 proteins/complex |
19 | Average MW of protein entity | 160 kD |
20 | Average size of mRNA | 1100 bases |
21 | Average length of mRNA | 370 nm |
22 | Average MW of all RNAs | 400 kD |
23 | Average MW of single DNA | 3.0x109 D or 3.0x106 kD |
24 | Average MW of all DNA | 7 x 106 kD |
25 | Average length of DNA (chrom.) | 1.55 mm |
26 | Diameter of chromosome | 490 um |
27 | Diameter of condensed chromosome | 17 um |
28 | Spacing between small organics | 3.6 nm/molecule |
29 | Spacing between ions | 2.1 nm/molecule |
30 | Ave. spacing between proteins | 7 nm/molecule |
31 | Spacing between protein entities | 9 nm/molecule |
32 | Mean Velocity of 70 kD protein (cytoplasm) | 3 nm/ms = 3x10-6 m/s |
33 | Mean Velocity of 40 kD protein (cytoplasm) | 5 nm/ms = 5x10-6 m/s |
34 | Mean Velocity of 30 kD protein (cytoplasm) | 7 nm/ms = 7x10-6 m/s |
35 | Mean Velocity of 14 kD protein (cytoplasm) | 10 nm/ms = 10x10-6 m/s |
36 | Mean Velocity of small molecules (cytoplasm) | 50 nm/ms = 5x10-5 m/s |
37 | Mean Velocity of protein in H2O | 27 nm/ms = 2.7x10-5 m/s |
38 | Mean Velocity of small molecules in H2O | 87 nm/ms = 8.7x10-5 m/s |
39 | Concentration of protein in cell | 200-320 mg/mL (5-8 mM) |
40 | Concentration of RNA in cell | 75-120 mg/mL (0.5-0.8 mM) |
41 | Concentration of DNA in cell | 11-18 mg/mL (5 nM) |
42 | Volume occupied by water | 70% |
43 | Volume occupied by protein | 17% |
44 | Volume occupied by all RNA | 6% |
45 | Volume occupied by rRNA | 5% |
46 | Volume occupied by tRNA | 0.8% |
47 | Volume occupied by mRNA | 0.2% |
48 | Volume occupied by DNA | 1% |
49 | Volume occupied by ribosomes | 8% |
50 | Volume occupied by lipid | 3% |
51 | Volume occupied by LPS | 1% |
52 | Volume occupied by murein | 1% |
53 | Volume occupied by glycogen | 1% |
54 | Volume occupied by ions | 0.3% |
55 | Volume occupied by small organics | 1% |
56 | Translation rate | 40 aa/sec |
57 | RNA polymerase transcription rate | 70 nt/sec |
Large Molecule Copy Numbers | ||
1 | Number of cell walls/cell | 1 |
2 | Number of membranes/cell | 2 |
3 | Number of chromosomes/cell | 2.3 (at mid log phase) |
4 | Number of mRNA/cell | 4000 |
5 | Number of rRNA/cell | 18,000 |
6 | Number of tRNA/cell | 200,000 |
7 | Number of all RNA/cell | 222,000 |
8 | Number of polysaccharides/cell | 39,000 |
9 | Number of murein molecules/cell | 240,000-700,000 |
10 | Number of lipopolysaccharide/cell | 600,000 |
11 | Number of lipids/cell | 25,000,000 |
12 | Number of all lipids/cell | 25,000,000 |
13 | Number of phosphatidylethanolamine | 18,500,000 |
14 | Number of phosphatidylglycerol | 5,000,000 |
15 | Number of cardiolipin | 1,200,000 |
16 | Number of phosphatidylserine | 500,000 |
17 | Number of LPS (MW = 10kD) | 600,000 |
18 | Average SA of lipid molecule | 25 Ang2 |
19 | Fraction of lipid bilayer=lipid | 40% |
20 | Fraction of lipid bilayer=protein | 60% |
21 | Number of outer membrane proteins | 300,000 |
22 | Number of porins (subset of OM) | 60,000 |
23 | Number of lipoproteins (OM) | 240,000 |
24 | Number of inner membrane proteins | 200,000 |
25 | Number of nuclear proteins | 100,000 |
26 | Number of cytoplasmic proteins | 1,000,000 (excluding ribo proteins) |
27 | Number of ribosomal proteins | 900,000 |
28 | Number of periplasmic proteins | 80,000 |
29 | Number of all proteins in cell | 2,600,000 |
30 | Number of external proteins (flag/pili) | 1,000,000 |
31 | Number of all proteins | 3,600,000 |
Statistics on Larger Molecule Complexes | ||
1 | Number of protein types to make flagella | 42 |
2 | Length of flagella | 10-20 um or ~15,000 nm |
3 | Diameter of flagella | 25 nm |
4 | Number of protofilaments in flagellum | 11 |
5 | Diameter of each fliC monomer | 5 nm |
6 | Number of fliC monomers in filament | 3000x11=33,000 |
7 | Number of flagella/cell | 10 |
8 | Number of fliC proteins | 330,000 |
9 | Speed at which E. coli move | 50 um/sec = 18 x10-5 km/h |
10 | Number of protein types to make pilus | 1 |
11 | Length of pili/fimbrae | 200-2000 nm |
12 | Diamter of pili | 6.5 nm |
13 | Number of papA/nm pilus | 1.5 |
14 | Number of papA monomers/pilus | 3000-30,000 |
15 | Number of pili/cell | 100-300 |
16 | Number of papA/cell | 300,000-900,000 |
17 | Number of ribosomes/cell | 18,000 |
18 | Number of protein types to make ribosome | 55 |
19 | Number rRNA types to make ribosome | 3 |
20 | Number of proteins in 30S subunit | 21 |
21 | Number of proteins in 50S subunit | 34 |
22 | Number of rRNA in 30S subunit | 1 |
23 | Number of rRNA in 50S subunit | 2 |
24 | Length of all rRNA | 5520 nt |
25 | MW of ribosome | 2700 kD |
26 | MW of RNA component | 1700 kD |
27 | MW of protein component | 1000 kD |
28 | Diameter of ribosome | 20 nm |
29 | Volume of ribosome | 4.2 x 10-24 m3 |
Small Molecule Copy Numbers | ||
1 | Number of water molecules/cell | 2.34x1010 (23.4 billion) |
2 | Number of ions/cell | 120,000,000 (300 mM) |
3 | Number of small organics/cell | 18,000,000 (40-50 mM) |
4 | Number of K ions | 90,000,000 (200-250 mM) |
5 | Number of Na ions | 2,000,000 (5 mM) |
6 | Na (in): Na (out) | 1:20 (in concentration) |
7 | Number of Ca ions | 2,300,000 (6 mM) |
8 | Number of free Ca ions | 40 (100 nM) |
9 | Number of Cl ions | 2,400,000 (6 mM) |
10 | Number of Mg ions | 4,000,000 (10 mM) |
11 | Number of Fe ions | 7,000,000 (18 mM) |
12 | Number of Mn ions | 1,700,000 (4 mM) |
13 | Number of Zn ions | 1,700,000 (4 mM) |
14 | Number of Mo ions | 1,700,000 (4 mM) |
15 | Number of Cu ions | 1,700,000 (4 mM) |
16 | Number of PO4 ions | 2,000,000 (5 mM) |
17 | Number of glucose/cell | 200,000-400,000 (0.5-1 mM) |
18 | Number of PEP/cell | 1,100,000 (2.8 mM) |
19 | Number of pyruvate/cell | 370,000 (0.9 mM) |
20 | Number of gluc-6-PO4/cell | 20,000 (0.05 mM) |
21 | Number of ATP/cell | 500,000 - 3,000,000 (1.3-7.0 mM) |
22 | Number of ADP/cell | 70,000 (0.17 mM) |
23 | Number of NADP/cell | 240,000 (0.63 mM) |
24 | Number of NADPH/cell | 220,000 (0.56 mM) |
25 | Number of all amino acids/cell | 6,000,000 (1.5 mM) |
26 | Number of free Alanine/cell | 350,000 (0.8 mM) |
27 | Number of free Cysteine/cell | 80,000 (0.2 mM) |
28 | Number of free Aspartate/cell | 530,000 (1.34 mM) |
29 | Number of free Glutamate/cell | 200,000 (0.5 mM) |
30 | Number of free Phenylalanine/cell | 170,000 (0.4 mM) |
31 | Number of free Glycine/cell | 350,000 (0.8 mM) |
32 | Number of free Histidine/cell | 80,000 (0.2 mM) |
33 | Number of free Isoleucine/cell | 200,000 (0.5 mM) |
34 | Number of free Lysine/cell | 190,000 (0.46 mM) |
35 | Number of free Leucine/cell | 300,000 (0.7 mM) |
36 | Number of free Methionine/cell | 40,000 (0.1 mM) |
37 | Number of free Asparagine/cell | 200,000 (0.5 mM) |
38 | Number of free Proline/cell | 200,000 (0.5 mM) |
39 | Number of free Glutamine/cell | 200,000 (0.5 mM) |
40 | Number of free Arginine/cell | 170,000 (0.4 mM) |
41 | Number of free Serine/cell | 300,000 (0.7 mM) |
42 | Number of free Threonine/cell | 1,400,000 (3.49 mM) |
43 | Number of free Valine/cell | 240,000 (0.6 mM) |
44 | Number of free Tryptophan/cell | 80,000 (0.2 mM) |
45 | Number of free Tyrosine/cell | 300,000 (0.7 mM) |
46 | Osmotic pressure (pushing out) | 75 lb/in2 |
E. coli Metabolism | ||
1 | 1 glucose generates (total) | 36-38 ATP |
2 | glycolysis yields | 6-8 ATP |
3 | oxidation of pyruvate yields | 6 ATP |
4 | Krebs cycle/e- transport yields | 24 ATP |
5 | Number ATP to make 1 DNA | 72,289,000 |
6 | Number ATP to make 1 protein (360 aa) | 1500 |
7 | Number ATP to make 1 lipid | 7 |
8 | Number ATP to make 1 polysaccharide | 2000 |
9 | Number ATP to make 1 RNA (1000 nt) | 2000 |
10 | Number ATP to make 1 cell | 55 billion ATP |
11 | Number Glucose molecules consumed | 1.4 billion molecules |
12 | Cell division rate | 1 division/30 minutes |
Labels:
SCIENCE AND TECHNOLOGY
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